계명대학교 의학도서관 Repository

Targeting orphan nuclear receptor SHP in the treatment of metabolic diseases

Metadata Downloads
Affiliated Author(s)
김미경박근규
Alternative Author(s)
Kim, Mi KyungPark, Keun Gyu
Journal Title
Expert Opinion on Therapeutic Targets
ISSN
1472-8222
Issued Date
2010
Abstract
Abstract



Importance of the field: The orphan nuclear receptor small heterodimer partner (SHP; NR0B2) is an atypical nuclear receptor that contains a ligand-binding domain, but lacks the conserved DNA-binding domain. Since its discovery, SHP has been identified as a key transcriptional regulatory factor of genes involved in diverse metabolic pathways.

Areas covered in this review: We performed a Medline/Pubmed search to find published studies on the role of SHP in the regulation of metabolism in the liver, pancreatic islets, blood vessel, and kidney and on the feasibility of using SHP as a therapeutic target in metabolic disease.

What the reader will gain: In this review, we discuss the function of SHP as regulator of cholesterol, lipid and glucose metabolism, and the role of SHP in metabolic and fibrotic diseases.

Take home message: The reviewed studies suggested that SHP could be a major target for therapeutic intervention in metabolic and fibrotic diseases, including metabolic syndrome and its complications. However, for SHP-targeted therapy, there are some outstanding issues, including the small number of known inducers of SHP and the lack of sufficient data in humans.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Mi-Kyung Kim et al. (2010). Targeting orphan nuclear receptor SHP in the treatment of metabolic diseases. Expert Opinion on Therapeutic Targets, 14(4), 453–466. doi: 10.1517/14728221003652463
Type
Article
ISSN
1472-8222
DOI
10.1517/14728221003652463
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35734
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록
  • 관련 파일이 존재하지 않습니다.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.