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Anti-allergic inflammatory activity of the fruit of Prunus persica: Role of calcium and NF-κB

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Affiliated Author(s)
권택규
Alternative Author(s)
Kwon, Taeg Kyu
Journal Title
Food and Chemical Toxicology
ISSN
0278-6915
Issued Date
2010
Abstract
Mast cell-mediated allergic symptoms are involved in many diseases, such as asthma and sinusitis. In this
study, we investigated the effect of ethanol extract of fruits of Prunus persica (L) Batsch (FPP) on the mast
cell-mediated allergic inflammation and studied the possible mechanism of action. FPP dose-dependently
inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic
reactions. Histamine releasing from mast cells was reduced by FPP, which was mediated by modulation
of intracellular calcium. In addition, FPP attenuated the phorbol 12-myristate 13-acetate and calcium ionophore
A23187 (PMACI)-stimulated expression and secretion of pro-inflammatory cytokines in human
mast cells. The inhibitory effect of FPP on pro-inflammatory cytokines was nuclear factor (NF)-jB dependent.
Our findings provide evidence that FPP inhibits mast cell-derived allergic inflammation and
involvement of calcium and NF-jB in these effects.
Department
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Tae-Yong Shin et al. (2010). Anti-allergic inflammatory activity of the fruit of Prunus persica: Role of calcium
and NF-κB. Food and Chemical Toxicology, 48(10), 2797–2802. doi: 10.1016/j.fct.2010.07.009
Type
Article
ISSN
0278-6915
DOI
10.1016/j.fct.2010.07.009
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35745
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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