Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression
by inhibiting ERK and NF-κB transcriptional activity
- Affiliated Author(s)
- 권택규
- Alternative Author(s)
- Kwon, Taeg Kyu
- Journal Title
- Food and Chemical Toxicology
- ISSN
- 0278-6915
- Issued Date
- 2010
- Abstract
- Monocyte chemoattractant protein-1 (MCP-1) is a potent mediator of macrophage migration and therefore,
plays an essential role in early events of inflammation. In the present study, we show the protein
kinase C activator, phorbol myristate acetate (PMA), potently induced mRNA expression and secretion
of the C-C chemokine MCP-1 in U937 cells. We found that curcumin, a natural biologically active compound
extracted from rhizomes of Curcuma species, significantly inhibited the PMA-induced increase
in MCP-1 expression and secretion. These effects of curcumin are dose dependent and correlate with
the suppression of MCP-1 mRNA expression levels. Curcumin inhibited PMA-mediated activation of
extracellular signal-regulated kinase (ERK) and NF-jB transcriptional activity. Therefore, one possible
anti-inflammatory mechanism of curcumin may be to inhibit the secretions of inflammatory MCP-1
chemokine.
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