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Role of Low- and High-Frequency Oscillations in the Human Hippocampus for Encoding Environmental Novelty During a Spatial Navigation Task

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Affiliated Author(s)
구정훈
Alternative Author(s)
Ku, Jeong Hun
Journal Title
Hippocampus
ISSN
1050-9631
Issued Date
2014
Abstract
The hippocampus plays a key role in the encoding and
retrieval of information related to novel environments during spatial
navigation. However, the neural basis for these processes in the human
hippocampus remains unknown because it is difficult to directly mea-
sure neural signals in the human hippocampus. This study investigated
hippocampal neural oscillations involved in encoding novel environ-
ments during spatial navigation in a virtual environment. Seven epilep-
tic patients with implanted intracranial hippocampal depth electrodes
performed three sessions of virtual environment navigation. Each session
consisted of a navigation task and a location-recall task. The navigation
task consisted of eight blocks, and in each block, the participant navi-
gated to the location of four different objects and was instructed to
remember the location of the objects. After the eight blocks were com-
pleted, a location-recall task was performed for each of the four
objects. Intracranial electroencephalography data were monitored dur-
ing the navigation tasks. Theta (5–8 Hz) and delta (1–4 Hz) oscillations
were lower in the first block (novel environment) than in the eighth
block (familiar environment) of the navigation task, and significantly
increased from block one to block eight. By contrast, low-gamma (31–
50 Hz) oscillations were higher in the first block than in the eighth
block of the navigation task, and significantly decreased from block one
to block eight. Comparison of sessions with high recall performance
(low error between identified and actual object location) and low recall
performance revealed that high-gamma (51–100 Hz) oscillations signifi-
cantly decreased from block one to block eight only in sessions with
high recall performance. These findings suggest that delta, theta, and
low-gamma oscillations were associated with encoding of environmen-
tal novelty and high-gamma oscillations were important for the success-
ful encoding of environmental novelty.
V
C
2014 Wiley Periodicals, Inc.
KEY WORDS: environmental novelty; low-fre-
quency oscillations; high-frequency oscillations; hip-
pocampus; intracranial electro-encephalography
Department
Dept. of Biomedical Engineering (의용공학과)
Publisher
School of Medicine
Citation
Jinsick Park et al. (2014). Role of Low- and High-Frequency Oscillations in the Human
Hippocampus for Encoding Environmental Novelty During
a Spatial Navigation Task. Hippocampus, 24(11), 1341–1352. doi: 10.1002/hipo.22315
Type
Article
ISSN
1050-9631
DOI
10.1002/hipo.22315
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35832
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
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