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Associations of EPHB1 polymorphisms with hepatocellular carcinoma in the Korean population

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Affiliated Author(s)
신동훈
Alternative Author(s)
Shin, Dong Hoon
Journal Title
Human Immunology
ISSN
0198-8859
Issued Date
2011
Abstract
Hepatocellular carcinoma (HCC) is a type of hypervascular tumor, and angiogenesis is important for HCC tumor
growth. Eph receptor B1 (EPHB1), amemberof the Eph family, mediates embryonic vascular system development
and adult angiogenesis. This receptor may be involved in carcinogenesis of the digestive tract. Our aim was to
examine the relationships between EPHB1 polymorphisms and HCC in the Korean population. Genomic DNA was
extracted from 182 patients with HCC and 266 healthy subjects. EPHB1 polymorphisms were determined by
polymerase chain reaction and direct sequencing. Multiple logistic regression models (log-additive, dominant,
and recessive models) were used for odds ratios, 95% confidence intervals, and p values. Five polymorphisms
(rs11929692, rs7644369, rs6776570, rs3821502, and rs6766459) of the EPHB1 gene and alleles of 2 polymorphisms
(rs1502174 and rs9877457) were associated with HCC (p 0.05 for both). Our results suggest that EPHB1
polymorphisms may be associated with susceptibility to HCC in the Korean population.
2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights
reserved.
Department
Dept. of Preventive Medicine (예방의학)
Publisher
School of Medicine
Citation
Su Kang Kim et al. (2011). Associations of EPHB1 polymorphisms with hepatocellular carcinoma in the
Korean population. Human Immunology, 72(10), 916–920. doi: 10.1016/j.humimm.2011.06.014
Type
Article
ISSN
0198-8859
DOI
10.1016/j.humimm.2011.06.014
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35838
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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