Predictors of 12-week remission in a nationwide cohort of
people with depressive disorders: the CRESCEND study
- Affiliated Author(s)
- 정성원
- Alternative Author(s)
- Jung, Sung Won
- Journal Title
- Human Psychopharmacology
- ISSN
- 0885-6222
- Issued Date
- 2011
- Abstract
- Objective To estimate the 12-week remission rate of patients with depressive disorders and predictors of this in a naturalistic clinical
setting in South Korea.
Methods For people with DSM-IV depressive disorders about to receive treatment at 18 hospitals, data on sociodemographic and health
status were obtained. A free choice of clinical interventions was allowed and naturalistic follow-up took place at 1, 2, 4, 8, and 12 weeks later.
Remission was defined as a Hamilton Depression Rating Scale score of 7 sustained to 12 weeks or last follow-up, if earlier.
Results For 723 participants, the 12-week remission rate was 31.4%. Remission was more likely in women, and in patients without a prior
history of suicide attempt, and those with lower baseline anxiety.
Conclusions Remission associated with unrestricted clinical interventions was comparable to STAR
D estimates for citalopram alone.
Comorbid anxiety and previous suicide attempt were markers of worse outcome. Copyright # 2011 John Wiley & Sons, Ltd.
key words — depression; remission; anxiety; parasuicide; Korea
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