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Phlorofucofuroeckol A Suppresses Expression of Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines via Inhibition of Nuclear Factor-κB, c-Jun NH2-Terminal Kinases, and Akt in Microglial Cells

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Affiliated Author(s)
장병철
Alternative Author(s)
Jang, Byeong Churl
Journal Title
Inflammation
ISSN
0360-3997
Issued Date
2013
Abstract
—Microglial activation has been implicated in many neurological disorders for its inflammatory
and neurotrophic effects. In this study, we investigated the effects of phlorofucofuroeckol A
isolated from Ecklonia stolonifera Okamura on the production of inflammatory mediators in lipopolysaccharide
(LPS)-stimulated microglia. Pre-treatment of phlorofucofuroeckol A attenuated the
productions of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in LPS-stimulated
microglia. Profoundly, phlorofucofuroeckol A treatment showed inactivation of nuclear factor-κB
(NF-κB) by preventing the degradation of inhibitor κB-α and the nuclear translocation of p65 NF-κB
subunit. Moreover, phlorofucofuroeckol A inhibited the activation of c-Jun NH2-terminal kinases
(JNKs), p38 mitogen-activated protein kinase (MAPK), and Akt, but not that of extracellular signalregulated
kinase. These results indicate that phlorofucofuroeckol A inhibits the LPS-induced expression
of inflammatory mediators through inactivation of NF-κB, JNKs, p38 MAPK, and Akt pathways.
These findings suggest that phlorofucofuroeckol A can be considered as a nutraceutical
candidate for the treatment of neuroinflammation in neurodegenerative diseases.
Department
Dept. of Molecular Medicine (분자의학)
Publisher
School of Medicine
Citation
A-Reum Kim et al. (2013). Phlorofucofuroeckol A Suppresses Expression of Inducible
Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory
Cytokines via Inhibition of Nuclear Factor-κB, c-Jun
NH2-Terminal Kinases, and Akt in Microglial Cells. Inflammation, 36(2), 259–271. doi: 10.1007/s10753-012-9542-6
Type
Article
ISSN
0360-3997
DOI
10.1007/s10753-012-9542-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35872
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
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