One-year clinical outcomes of everolimus- versus sirolimus-eluting
stents in patients with acute myocardial infarction
- Affiliated Author(s)
- 허승호
- Alternative Author(s)
- Hur, Seung Ho
- Journal Title
- International Journal of Cardiology
- ISSN
- 0167-5273
- Issued Date
- 2014
- Abstract
- Background: In contrast to many studies comparing everolimus-eluting stent (EES) with paclitaxel-eluting stent
(PES), data directly comparing EES with sirolimus-eluting stent (SES) are limited, especially in patients with
acute myocardial infarction (AMI).
Methods: This study includes 2911 AMI patients treated with SES (n= 1264) or EES (n= 1701) in Korea Acute
Myocardial Infarction Registry (KAMIR). Propensity scorematching was applied to adjust for baseline imbalance
in clinical and angiographic characteristics, yielding a total of 2400 well-matched patients (1200 receiving SES
and 1200 receiving EES). One-year clinical outcomeswere compared between the two propensity scorematched
groups.
Results: Baseline clinical and angiographic characteristics were similar between the two propensity score
matched groups. One-year clinical outcomes of the propensity score matched cohort were comparable between
the EES versus the SES groups including the rates of cardiac death (4.8% vs. 4.8%, P= 1.000), recurrent myocardial
infarction (1.4% vs. 1.7%, P= 0.619), target lesion revascularization (1.4% vs. 1.6%, P= 0.737), target lesion
failure (7.0% vs. 7.3%, P= 0.752), and probable or definite stent thrombosis (0.5% vs. 0.9%, P= 0.224) except for a
trend toward lower incidence of target vessel revascularization (1.9% vs. 3.0%, P= 0.087) and a lower rate of total
major adverse cardiac events (9.3% vs. 11.9%, P = 0.034) in the EES group.
Conclusions: The present propensity scorematched analysis performed in a large-scale, prospective, multicenter
registry suggests that the second-generation drug-eluting stent EES has at least comparable or even better safety
and efficacy profiles as compared with SES in the setting of AMI.
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