Waldeyer’s ring marginal zone B cell lymphoma: are the clinical
and prognostic features nodal or extranodal? A study
by the Consortium for Improving Survival of Lymphoma (CISL)
- Affiliated Author(s)
- 도영록
- Alternative Author(s)
- Do, Young Rok
- Journal Title
- International Journal of Hematology
- ISSN
- 0925-5710
- Issued Date
- 2012
- Abstract
- There has been controversy surrounding
Waldeyer’s ring (WR), especially focused on the question
of whether it should be regarded as a nodal or an
extranodal site. We conducted retrospective analyses
of marginal zone B cell lymphomas involving WR
(WR-MZLs) to observe their clinical features and prognosis,
with specific regard to the nodal-or-extranodal
question. A total of 52 patients with histological diagnosis
of WR-MZL were retrospectively analyzed. The most
common involvement site was the tonsil (40.4 %). Ann
Arbor stage III/VI disease was present in 48.1 % (25 of
52). The response rate of the 27 stage I/II patients was
88.9 %, with 21 complete remissions and three partial
remissions. The median time to progression (TTP) was
3.7 years (95 % CI 2.5–4.9 years). The estimated 5-year
TTP and overall survival rates were 39.4 and 90.5 %,
respectively. In a comparison with the historical data
regarding extra-WR MALT lymphoma and nodal MZL
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