PIK3CA Amplification Is Common in Left Side-Tubular
Adenomas but Uncommon Sessile Serrated Adenomas
Exclusively with KRAS Mutation
- Affiliated Author(s)
- 이현수; 이재호; 최인장; 김대광; 황일선; 강유나; 김신
- Alternative Author(s)
- Lee, Hyun Su; Lee, Jae Ho; Choi, In Jang; Kim, Dae Kwang; Hwang, Il Seon; Kang, Yu Na; Kim, Shin
- Journal Title
- International Journal of Medical Sciences
- ISSN
- 1449-1907
- Issued Date
- 2015
- Abstract
- Colorectal cancer is a heterogeneous disorder than arises via multiple distinct pathways, from
tubular adenomas (TAs) and sessile serrated adenomas (SSAs), which are clinically, morphologically,
and molecularly different. We examined PIK3CA amplification in colorectal precancerous
legions, including TAs and SSAs. DNA was isolated from paired normal and tumoral tissues in 64
TAs and 32 SSAs. PIK3CA amplification, KRAS mutation, and BRAF mutation were analyzed by
real-time PCR and pyrosequencing. PIK3CA amplification was found in 25% of TAs and 9.4% of
SSAs, respectively. KRAS and BRAF mutations were mutually exclusive in both TAs and SSAs. In
TAs, PIK3CA amplification was associated with left side and it was mutually exclusive with KRAS
mutation. These results suggest that PIK3CA amplification may be early and important event in
colorectal carcinogenesis and may drive the development of left-side TAs independently with
KRAS mutation.
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