Modulation of cell death sensitivity by mutant p53 in HCV core-expressing cells

Authors
Jae-We ChoKun ParkGi Ryang KweonJong-Chun ParkJe-Chul LeeWon-Ki BaekByeong-Churl JangSeong-Il SuhMin-Ho Suh
Department
Dept. of Microbiology (미생물학); Dept. of Dermatology (피부과학); Dept. of Molecular Medicine (분자의학)
Issue Date
2005
Citation
International Journal of Molecular Medicine, Vol.15(3) : 475-480, 2005
ISSN
1107-3756
Abstract
The hepatitis C virus (HCV) core protein plays important roles in hepatocarcinogenesis through modulation of cellular proliferation, apoptosis, and immunological responses. The roles of core protein in apoptosis have been conflicting; both proapoptotic and anti-apoptotic roles have been reported from different experimental conditions. Nonetheless, the overcoming apoptosis is a key molecular event to development of hepatocellular carcinoma. We investigated whether the HCV core-expressing cells are susceptible to apoptosis after cellular stress. Furthermore, we focused on the possibility that the presence of mutant p53 can render cells resistant to apoptosis. Our data clearly indicated that core-expressing cells showed increased apoptotic cell death through caspase-3 activation pathways after genotoxic stress without modulation of Bcl-2 family proteins. However, core-expressing cells, when transiently transfected with mutant p53, showed markedly increased resistance upon apoptosis after genotoxic stress. Thus, our data suggest that even though HCV core-expressing cells are susceptible to apoptosis after genotoxic stress, cells are resistant to apoptosis under mutant p53, implying a functional abnormality of p53 giving a chance to overcome apoptosis and ultimately cells develop into hepatocellular cell carcinoma.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35914
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
Keimyung Author(s)
백원기; 서성일; 서민호; 조재위; 장병철
Full Text
https://www.spandidos-publications.com/ijmm/15/3/475
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