계명대학교 의학도서관 Repository

Curcumin attenuates the expression of IL-1ß, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstream targets

Metadata Downloads
Affiliated Author(s)
조재위이규석김창욱
Alternative Author(s)
Cho, Jae WeLee, Kyu SukKim, Chang Wook
Journal Title
International Journal of Molecular Medicine
ISSN
1107-3756
Issued Date
2007
Abstract
. TNF-· induces some proinflammatory cytokines
including IL-1ß, IL-6, IL-8, and itself by activation of NF-κB
or MAPKs (p38, JNK, ERK). These cytokines play important
roles in various inflammatory skin diseases, such as psoriasis.
Recently it was also reported that expression of cyclin E is upregulated
by ERK pathway after TNF-· treatment. However,
it was unknown whether curcumin, showing inhibitory effects
on NF-κB and MAPKs, attenuates the expression of TNF-·-
induced IL-1ß, IL-6, IL-8, and TNF-· as well as cyclin E
expression in HaCaT cells. In this study, we investigated the
inhibitory effect of curcumin on expression of proinflammatory
cytokines and cyclin E in TNF-·-treated HaCaT cells. We
found that curcumin inhibited the expression of TNF-·-induced
IL-1ß, IL-6, and TNF-·, but not IL-8, in TNF-·-treated HaCaT
cells as well as the TNF-·-induced cyclin E expression. In
addition, curcumin inhibited the activation of MAPKs (JNK,
p38 MAPK, and ERK) and NF-κB in TNF-·-treated HaCaT
cells. Taken together, curcumin exerts anti-inflammatory and
growth inhibitory effects in TNF-·-treated HaCaT cells through
inhibition of NF-κB and MAPK pathways.
Department
Dept. of Dermatology (피부과학)
Publisher
School of Medicine
Citation
JAE-WE CHO et al. (2007). Curcumin attenuates the expression of IL-1ß, IL-6, and
TNF-α as well as cyclin E in TNF-α-treated HaCaT cells;
NF-κB and MAPKs as potential upstream targets. International Journal of Molecular Medicine, 19(3), 469–474. doi: 10.3892/ijmm.19.3.469
Type
Article
ISSN
1107-3756
DOI
10.3892/ijmm.19.3.469
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35923
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.