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Anticancer effects and molecular mechanisms of epigallocatechin-3-gallate

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Affiliated Author(s)
권택규
Alternative Author(s)
Kwon, Taeg Kyu
Journal Title
Integrative Medicine Research
ISSN
2213-4220
Issued Date
2014
Abstract
tEpigallocatechin-3-gallate (EGCG) is a type of catechin found in green tea. EGCG exhibits avariety of activities, including anti-inflammatory, antidiabetes, antiobesity, and antitumor.In this review, we focus on the antitumor effects of EGCG. EGCG inhibits carcinogen activity,tumorigenesis, proliferation, and angiogenesis, and induces cell death. These effects areassociated with modulation of reactive oxygen species (ROS) production. Although EGCGhas a dual function of antioxidant and pro-oxidant potential, EGCG-mediated modulationof ROS production is reported to be responsible for its anticancer effects. The EGCG-mediatedinhibition of nuclear factor- B signaling is also associated with inhibition of migration,angiogenesis, and cell viability. Activation of mitogen-activated protein kinases activityupregulates the anticancer effect of EGCG on migration, invasion, and apoptosis. In addi-tion, EGCG could also induce epigenetic modification by inhibition of DNA methyltransferaseactivity and regulation of acetylation on histone, leading to an upregulation of apoptosis.Although EGCG promotes strong anticancer effects by multiple mechanisms, further studiesare needed to define the use of EGCG in clinical treatment.
Department
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Kyoung-jin Min and Taeg Kyu Kwon. (2014). Anticancer effects and molecular mechanisms of
epigallocatechin-3-gallate. Integrative Medicine Research, 3(1), 16–24. doi: 10.1016/j.imr.2013.12.001
Type
Article
ISSN
2213-4220
DOI
10.1016/j.imr.2013.12.001
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35948
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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