Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo

Authors
JAE-WE CHOSUN-YOUNG CHOSEONG-RYONG LEEKYU-SUK LEE
Department
Dept. of Dermatology (피부과학); Dept. of Pharmacology (약리학)
Issue Date
2010
Citation
International Journal of Molecular Medicine, Vol.25(3) : 347-352, 2010
ISSN
1107-3756
Abstract
. A scar is usually developed by an imbalance of collagen synthesis and degradation. It is believed that the flavonoids (quercetin and kaempferol) in onion extract play a role in reducing scar formation through inhibition of fibroblast activities. Even though several commercial products are composed of onion extract, the precise molecular mechanisms of onion extract in reduction of scar formation in skin are still largely unknown. In this study we investigated the effect both of onion extract and quercetin on the proliferation of fibroblasts, expression of type I collagen and matrix metalloproteinase-1 (MMP-1). Our data show that proliferation rates of fibroblasts were decreased in a dose-dependent manner of the onion extract and quercetin. The expression of type I collagen was not markedly changed by the onion extract and quercetin. Interestingly, the expression of MMP-1 was markedly increased by both onion extract and quercetin in vitro and in vivo. Thus, our data indicate that onion extract and quercetin play a role in the anti-scar effect in skin through up-regulation of MMP-1 expression, implying this agent is a promising material for reducing scar formation.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35961
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
Keimyung Author(s)
조재위; 이규석; 이성용
Full Text
https://www.spandidos-publications.com/ijmm/25/3/347
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