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Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo

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Affiliated Author(s)
조재위이규석이성용
Alternative Author(s)
Cho, Jae WeLee, Kyu SukLee, Seong Ryong
Journal Title
International Journal of Molecular Medicine
ISSN
1107-3756
Issued Date
2010
Abstract
. A scar is usually developed by an imbalance of
collagen synthesis and degradation. It is believed that the
flavonoids (quercetin and kaempferol) in onion extract play a
role in reducing scar formation through inhibition of fibroblast
activities. Even though several commercial products are
composed of onion extract, the precise molecular mechanisms
of onion extract in reduction of scar formation in skin are still
largely unknown. In this study we investigated the effect both
of onion extract and quercetin on the proliferation of fibroblasts,
expression of type I collagen and matrix metalloproteinase-1
(MMP-1). Our data show that proliferation rates of fibroblasts
were decreased in a dose-dependent manner of the onion
extract and quercetin. The expression of type I collagen
was not markedly changed by the onion extract and quercetin.
Interestingly, the expression of MMP-1 was markedly
increased by both onion extract and quercetin in vitro and in
vivo. Thus, our data indicate that onion extract and quercetin
play a role in the anti-scar effect in skin through up-regulation
of MMP-1 expression, implying this agent is a promising
material for reducing scar formation.
Department
Dept. of Dermatology (피부과학)
Dept. of Pharmacology (약리학)
Publisher
School of Medicine
Citation
JAE-WE CHO et al. (2010). Onion extract and quercetin induce matrix
metalloproteinase-1 in vitro and in vivo. International Journal of Molecular Medicine, 25(3), 347–352. doi: 10.3892/ijmm_00000351
Type
Article
ISSN
1107-3756
DOI
10.3892/ijmm_00000351
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35961
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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