계명대학교 의학도서관 Repository

Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients

Metadata Downloads
Author(s)
Chang-Ho JeonHan-IL LeeIm-Hee ShinJong-Wook Park
Keimyung Author(s)
Park, Jong Wook
Department
Dept. of Immunology (면역학)
Journal Title
International Journal of Colorectal Disease
Issued Date
2008
Volume
23
Issue
1
Abstract
Background and aim Colorectal cancer (CRC) is one of the
most rapidly increasing cancers in Korea, but no comprehensive
analysis has been performed to speculate the
genetic basis of CRC development. We investigated the
presence of adenomatous polyposis coli gene (APC),
Kirsten-ras (K-ras), p53, microsatellite instability (MSI),
and melanoma antigen gene (MAGE) alterations in CRC
and correlated the results obtained with clinical data.
Materials and methods We collected 78 cancer tissues from
CRC patients. Genetic analyses were performed on APC,
K-ras, p53, and MSI (BAT 25 and BAT 26), and in addition,
MAGE expression was tested by reverse transcription
polymerase chain reaction. Correlations between genetic
markers and clinical factors were analyzed after reviewing
medical records.
Result The positive rates for alterations of APC, K-ras,
p53, MSI, and MAGE in 78 tissue samples were 33.3, 29.5,
34.6, 9.0, and 68.4%, respectively. Mutations were frequently
detected in codons 1291 and 1450 of APC, in
codon 12 of K-ras and in codons 248, 282, and 176 of p53.
APC mutations were frequently noted in early-stage cancer,
whereas MSI was observed in right-sided and multiple
cancers. No associations were found between the presence
of alterations in APC, K-ras, p53, MSI, and MAGE.
Interpretation In Koreans, positive rates of alterations in
APC and p53 were slightly lower than those of APC and
p53 in Caucasians, and the genetic alterations including
MAGE expression are involved in 92.1% of CRCs. The
lack of multiple mutations and of a relation between
mutation rates and clinical stage suggest that genetic
alterations might have independent influences on CRC
development in Koreans.
Keimyung Author(s)(Kor)
박종욱
Publisher
School of Medicine
Citation
Chang-Ho Jeon et al. (2008). Genetic alterations of APC, K-ras, p53, MSI, and MAGE
in Korean colorectal cancer patients. International Journal of Colorectal Disease, 23(1), 29–35. doi: 10.1007/s00384-007-0373-0
Type
Article
ISSN
0179-1958
Source
http://lps3.link.springer.com.proxy.dsmc.or.kr/article/10.1007%2Fs00384-007-0373-0
DOI
10.1007/s00384-007-0373-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35975
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.