A Web-Based Nomogram Predicting Para-aortic Nodal Metastasis in Incompletely Staged Patients With Endometrial Cancer A Korean Multicenter Study

Abstract

Objective: The purpose of this study is to develop a Web-based nomogram for predicting the individualized risk of para-aortic nodal metastasis in incompletely staged patients with endometrial cancer. Methods: From 8 institutions, the medical records of 397 patients who underwent pelvic and para-aortic lymphadenectomy as a surgical staging procedure were retrospectively reviewed. A multivariate logistic regression model was created and internally validated by rigorous bootstrap resampling methods. Finally, the model was transformed into a userfriendly Web-based nomogram (http://www.kgog.org/nomogram/empa001.html). Results: The rate of para-aortic nodal metastasis was 14.4% (57/397 patients). Using a stepwisevariable selection, 4 variables including deepmyometrial invasion, nonYendometrioid subtype, lymphovascular space invasion, and log-transformed CA-125 levels were finally adopted. After 1000 repetitions of bootstrapping, all of these 4 variables retained a significant association with para-aortic nodal metastasis in the multivariate analysisVdeep myometrial invasion (P = 0.001), nonYendometrioid histologic subtype (P = 0.034), lymphovascular space invasion (P = 0.003), and log-transformed serum CA-125 levels (P = 0.004). The model showed good discrimination (C statistics = 0.87; 95% confidence interval, 0.82Y0.92) and accurate calibration (Hosmer-Lemeshow P = 0.74). Conclusions: This nomogram showed good performance in predicting para-aortic metastasis in patients with endometrial cancer. The tool may be useful in determining the extent of lymphadenectomy after incomplete surgery. Key Words: Endometrial cancer, Lymph node, Lymphadenectomy, Metastasis, Para-aortic, Staging