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A Plasmacytoid Dendritic Cells-Type Ⅰ Interferon Axis Is Critically Implicated in the Pathogenesis of Systemic Lupus Erythematosus

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Affiliated Author(s)
김지민
Alternative Author(s)
Kim, Ji Min
Journal Title
International Journal of Molecular Sciences
ISSN
1661-6596
Issued Date
2015
Abstract
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that is
characterized by the generation of immune responses to various nuclear components.
Impaired clearance of apoptotic cells and loss of tolerance to self-antigens are involved
both in the initiation and in the propagation of the disease. Dendritic cells (DCs) are key
factors in the balance between autoimmunity and tolerance and play a role linking innate
and adaptive immunity. DCs, particularly plasmacytoid DCs (pDCs), are the main source
of type I interferon (IFN) cytokines, which contribute to the immunopathogenesis of SLE.
There is accumulating evidence that pDCs and type I IFN cytokines take the leading part in
the development of SLE. In this review, we discuss recent data regarding the role of pDCs
and type I IFN cytokines in the pathogenesis of SLE and the potential for employing
therapies targeting against aberrant regulation of the pDC-type I IFN axis for treating SLE.
Keywords: systemic lupus erythematosus; dendritic cells; type I interferon
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Ji-Min Kim et al. (2015). A Plasmacytoid Dendritic Cells-Type Ⅰ Interferon Axis Is
Critically Implicated in the Pathogenesis of Systemic
Lupus Erythematosus. International Journal of Molecular Sciences, 16(6), 14158–14170. doi: 10.3390/ijms160614158
Type
Article
ISSN
1661-6596
DOI
10.3390/ijms160614158
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35995
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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