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Clinical Impliaction of Carotid-Radial Pulse Wave Velocity for Patients with Coronary Artery Disease

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Affiliated Author(s)
남창욱한성욱허승호김윤년김권배
Alternative Author(s)
Nam, Chang WookHan, Seong WookHur, Seung HoKim, Yoon NyunKim, Kwon Bae
Journal Title
Korean Circulation Journal
ISSN
1738-5520
Issued Date
2006
Keyword
PulseAtherosclerosisCoronary artery disease
Abstract
Background and Objectives : Arterial stiffness assessed non-invasively with the aortic pulse wave velocity (PWV) has been associated with atherosclerosis in the coronary arteries and also cardiovascular mortality. The aim of this study was to determine whether arterial stiffness may predict the severity of coronary artery disease (CAD). Subjects and Methods : We enrolled 106 consecutive, symptomatic patients (males: 71 (67%), mean age: 57.0±10.5 years) who underwent coronary angiography. The extent of the CAD was defined by single or multiple vessel disease according to the number of coronary vessels with a ≥50% narrowing, the lesion type according to the AHA/ACC guidelines, and a modified stenosis scoring system. Arterial stiffness was characterized by measurement of the carotid-radial PWV. In addition, such cardiovascular risk factors as the body mass index, hypertension, smoking, LDL-and HDL-cholesterol, ejection fraction (EF), left ventricle mass index (LVMI), pulse pressure, plasma homocysteine and C-reactive protein (CRP) were evaluated. Results : The carotid-radial PWV in multiple vessel CAD was faster than in single vessel CAD and the normal arteries (10.33±1.46 vs. 8.76±1.65 m/sec, respectively, p<0.001). On the univariate analysis, the extent of the CAD, as expressed as a modified stenosis score, was associated with the total cholesterol, LDL-cholesterol, the EF and the PWV. However, on the multivariate analysis, the extent of CAD was associated with the carotid-radial PWV (p<0.001).
Conclusion : Arterial stiffness identified by carotid-radial PWV may predict the severity of the CAD after adjusting for other cardiovascular risk factors.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Young-Soo Lee et al. (2006). Clinical Impliaction of Carotid-Radial Pulse Wave Velocity for Patients with Coronary Artery Disease. Korean Circulation Journal, 36(8), 565–572. doi: 10.4070/kcj.2006.36.8.565
Type
Article
ISSN
1738-5520
DOI
10.4070/kcj.2006.36.8.565
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36045
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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