건강한 성인에서 카페인이 동맥 강직도에 미치는 단기간의 영향

Other Titles
Acute Effects of Caffeine on Arterial Stiffness in Young Healthy Subjects
Authors
박창욱김기식이영수남창욱이상훈한성욱허승호김윤년김권배
Department
Dept. of Internal Medicine (내과학)
Issue Date
2005
Citation
Korean Circulation Journal, Vol.35(11) : 841-846, 2005
ISSN
1738-5520
Abstract
BACKGROUND AND OBJECTIVES : Coffee is one of the most popular beverages in the world. Caffeine is one of the substances contained in coffee and it is well known to increase blood pressure and the peripheral vascular resistance, in part because it stimulates the sympathetic nervous system. Arterial stiffness is an important factor for the performance of the cardiovascular system and it is an independent prognosticator of cardiovascular disease. We investigated the acute effect of caffeine on arterial stiffness in young healthy subjects. SUBJECTS AND METHODS: We enrolled 20 young healthy subjects, who were randomly divided two groups. The caffeine group (10 subjects, 4 males, mean age: 23.3±1.1 years) received 520 mL caffeinated coffee and the control group (10 subjects, 4 males, mean age: 23.1±1.3 years) received 520 mL water. The arterial stiffness was evaluated by the carotid-radial pulse wave velocity and the augmentation index as corrected by heart rate (75 bpm), and all the hemodynamic measurements were obtained at baseline, 30, 60, 120 and 180 minutes after ingestion of the coffee or water. RESULTS: Arterial stiffness measured by carotid-radial pulse wave velocity increased progressively from 9.4±1.2 m/sec at baseline to 11.5±1.6 m/sec (p<0.05) at 30 minutes after the coffee intake. In addition, peripheral systolic pressure increased progressively from 107.1±10.2 mmHg at baseline to 114.4±12.9 mmHg (p<0.05) at 60 minutes after the coffee intake. Such changes were not seen in control group. CONCLUSION: Caffeine affects increased the pulse wave velocity and systolic blood pressure. This means that coffee might have an adverse effect on arterial stiffness.
Keywords
CaffeinePulseArteries
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/36071
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
김기식; 남창욱; 한성욱; 허승호; 김윤년; 김권배
File in this Item
oak-aaa-03314.pdf(549.38 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE