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Topical fibronectin treatment in persistent corneal epithelial defects and corneal ulcers

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Affiliated Author(s)
김기산오준섭
Alternative Author(s)
Kim, Ki SanOh, Joon Sup
Journal Title
Korean Journal of Ophthalmology
ISSN
1011-8942
Issued Date
1990
Keyword
autologous fibronectinhomologous fibronectinpersistent corneal epithelial defectcorneal ulcer
Abstract
Topical fibronectin, autologous and homologous, was used to treat nine patients (eleven eyes) with persistent corneal epithelial defects and corneal ulcers that failed to improve with standard therapy. The fibronectin was purified from autologous and homologous plasma by gelatin-Sepharose 4B affinity chromatography and administered topically, 500 micrograms/ml five times a day, for three weeks. Complete or nearly complete reepithelialization was achieved in all patients regardless of the source of fibronectin, autologous or homologous. But healing times varied. The average healing time was 41.7 ± 14.7 days (35.7 ± 12.4 days for autologous, 50.8 ±14.4 days for homologous). Ocular symptoms were relieved significantly, and no side effects were observed. Over an average follow-up period of 5.2 months, no recurrences were noted. The results showed that homologous, as well as autologous, fibronectin was effective in patients with persistent corneal epithelial defects and corneal ulcers.
Department
Dept. of Ophthalmology (안과학)
Publisher
School of Medicine
Citation
Ki-San Kim et al. (1990). Topical fibronectin treatment in persistent corneal epithelial defects and corneal ulcers. Korean Journal of Ophthalmology, 4(1), 5–11. doi: 10.3341/kjo.1990.4.1.5
Type
Article
ISSN
1011-8942
DOI
10.3341/kjo.1990.4.1.5
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36182
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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