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Correlation between Claudins Expression and Prognostic Factors in Prostate Cancer

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Author(s)
김병훈김천일장혁수박철희최미선
Alternative Author(s)
Kim, Byung HoonKim, Chun IlChang, Hyuk SooPark, Choal HeeChoe, Mi Sun
Publication Year
2010
Keyword
Claudin 1CLDN5 proteinProstate-specific antigenProstatic neoplasms
Abstract
Purpose: The purpose of this study was to evaluate the correlation between the expression of claudins and prognostic factors in patients with prostate cancer. Materials and Methods: The subjects of this study were 48 patients who had undergone surgery for prostate cancer. The Gleason score (6 or lower, 7 or higher), prostate-specific antigen (PSA) level, T stage, biochemical recurrence, local recurrence, and distant
metastasis were compared according to the expression of claudin-1 and claudin-5 in prostate cancer. Results: In the group with a low expression of claudin-1, the Gleason score was 7 points or higher in 18 cases (82%) and 6 points or lower in 4 cases (18%). In the group with
a high expression of claudin-1, the Gleason score was 7 points or higher in 13 cases (50%) and 6 points or lower in 13 cases (50%). Thus, the low-expression group had more cases with a Gleason score of 7 or higher (p=0.022). The group with a low expression of claudin-5 also had more cases with a Gleason score of 7 or higher (p=0.011). The mean PSA values in the groups with a low and high expression of claudin-1 were 9.6 ng/ml and 5.6 ng/ml, respectively (p=0.007). A low expression of claudin-5 was also associated with a high PSA value (p=0.002). There was no statistical difference in the expression of claudin-1 and claudin-5 by T stage, biochemical recurrence, local recurrence, or distant metastasis. Conclusions: The low expression of claudin-1, claudin-5 was associated with a Gleason score of 7 or higher and a high PSA value in prostate cancer.
Department
Dept. of Urology (비뇨의학)
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
Korean Journal of Urology, Vol.51(4) : 239-244, 2010
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2010.51.4.239
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/36252
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