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Correlation between Chemokine Receptor CXCR4 Expression and Prognostic Factors in Patients with Prostate Cancer

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Author(s)
Seok Jin JungChun Il KimChoal Hee ParkHyuk Soo ChangByung Hoon KimMi Sun ChoiHyea Ra Jung
Publication Year
2011
Keyword
CXCR4ReceptorPrognosisProstate neoplasms
Abstract
Purpose: We evaluated the correlation between the expression of CXCR4 and prognostic factors in patients with prostate cancer.
Materials and Methods: A total of 57 patients who had undergone surgery for prostate cancer were enrolled. Specimens were obtained before any treatment and were stained with antihuman CXCR4 antibody. The intensity of staining was graded as low or high. The age, pretreatment prostate-specific antigen (PSA) level, Gleason score, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of CXCR4 in patients with prostate cancer. Results: Local recurrence was higher in the group with high expression, in 11 of 36 cases (30.6%), than in the group with low expression, in 1 of 21 cases (4.8%), with statistical significance (p=0.040). Distant metastasis was also associated with expression, occurring in 10 of 36 cases (27.8%) in the group with high expression and in 1 of 21 cases
(4.8%) in the group with low expression (p=0.041). In the logistic regression test, CXCR4 expression was the only factor in determining local recurrence (p=0.016) and distant metastasis (0.022). Furthermore, the group with high CXCR4 expression showed significantly
longer cancer-specific survival than did the low expression group (p=0.041). CXCR4 showed no association with age (p=0.881), pretreatment PSA level (p=0.584), Gleason score (p=0.640), T stage (p=0.967), or biochemical recurrence (p=0.081). Conclusions: The high expression of CXCR4 was associated with local recurrence and distant metastasis. CXCR4 expression was shown to be a useful prognostic factor for
patients with prostate cancer.
Department
Dept. of Urology (비뇨의학)
Dept. of Pathology (병리학)
Publisher
school of Medicine
Citation
Korean Journal of Urology, Vol.52(9) : 607-611, 2011
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2011.52.9.607
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/36253
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