Clinical Outcome and Prognosis of Patients with Primary Sinonasal Tract Diffuse Large B Cell Lymphoma Treated with R-CHOP Chemotherapy; A Study by the Consortium for Improving Survival for Lymphoma
- Affiliated Author(s)
- 도영록
- Alternative Author(s)
- Do, Young Rok
- Journal Title
- Leukemia & Lymphoma
- ISSN
- 1042-8194
- Issued Date
- 2015
- Keyword
- Diffuse large cell lymphomas; nasal cavities; paranasal sinus; rituximab
- Abstract
- We evaluated the clinical outcomes and relapse patterns of 80 patients with primary sinonasal tract diffuse large B-cell lymphoma(SN-DLBCL)treatedwithrituximab-cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) chemotherapy at 22 institutions. A total of 59 (73.8%) patients received R-CHOP chemotherapy alone, whereas 21 (26.3%) were treated with R-CHOP followed by involved field radiotherapy (IFRT). In 73 patients with Ann Arbor stage Ml disease, no significant difference was found in the response rate or overall survival (OS) between R-CHOP alone (n = 52) and R-CHOP followed by IFRT (n = 21). Among 11 relapsed patients in this study, the most common pattern of relapse was local (n = 8, 11.8%), whereas central nervous system (CNS) relapse was observed in only one (1.9%) patient. These results suggest that patients with primary SN-DLBCL treated with R-CHOP have a relatively low CNS relapse rate and better OS compared to previous studies before the introduction of R.
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