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dc.contributor.authorGeun-Ho Kim-
dc.contributor.authorDae-Kyu Song-
dc.contributor.authorChi-Heum Cho-
dc.contributor.authorSun Kyun Yoo-
dc.contributor.authorDae-Kwang Kim-
dc.contributor.authorGi-Young Park-
dc.contributor.authorSeong-il Suh-
dc.contributor.authorByeong-Churl Jang-
dc.contributor.authorJeong-Geun Lim-
dc.date.accessioned2018-08-10T00:30:55Z-
dc.date.available2018-08-10T00:30:55Z-
dc.date.issued2006-
dc.identifier.citationLife Science, Vol.79(7) : 622-628, 2006-
dc.identifier.issn0024-3205-
dc.identifier.otheroak-aaa-03660-
dc.identifier.urihttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/36300-
dc.description.abstractN-acetylcysteine (NAC), an antioxidant and a precursor of glutathione, is currently in clinical use for various pathological conditions. No data is available as to the relationship between NAC and muscular cell proliferation or muscular degenerative disease. In this study, we assessed the effect of NAC on growth of L6 myoblasts, a rat skeletal muscle cell line, under normal or bupivacaine-treated condition. Of interest, under normal growth conditions, NAC treatment concentration-dependently increased viability, cell number, and DNA incorporation of L6 cells. Remarkably, NAC treatment for 12 to 24 h led to increased phosphorylation of ERKs, a family of mitogen-activated protein kinase known to involve in cell proliferation, in L6 cells, and specific inhibition of ERKs by PD98059, a selective inhibitor of ERKs, greatly abolished the ability of NAC to increase the number of L6 cells. More importantly, pretreatment with NAC effectively blocked decrease in the number and ERKs phosphorylation in L6 cells induced by the exposure of bupivacaine, a local anesthetic with myotoxicity. These results collectively suggest that NAC has muscular cell proliferative and protective effects and the effects by NAC appear to be, in part, mediated via increase in ERKs activation.-
dc.description.statementofresponsibilityrestriction-
dc.publisherSchool of Medicine-
dc.rightsBY_NC_ND-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kr-
dc.subjectNAC-
dc.subjectL6 myoblasts-
dc.subjectBupivacaine-
dc.subjectERKs-
dc.titleMuscular cell proliferative and protective effects of N-acetylcysteine by modulating activity of extracellular signal-regulated protein kinase-
dc.typeArticle-
dc.contributor.localauthor임정근-
dc.contributor.localauthor조치흠-
dc.contributor.localauthor김대광-
dc.contributor.localauthor박기영-
dc.contributor.localauthor서성일-
dc.contributor.localauthor송대규-
dc.contributor.localauthor장병철-
dc.contributor.alternativelocalauthorLim, Jeong Geun-
dc.contributor.alternativelocalauthorCho, Chi Heum-
dc.contributor.alternativelocalauthorKim, Dae Kwang-
dc.contributor.alternativelocalauthorPark, Gi Young-
dc.contributor.alternativelocalauthorSuh, Seong Il-
dc.contributor.alternativelocalauthorSong, Dae Kyu-
dc.contributor.alternativelocalauthorJang, Byeong Churl-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.departmentDept. of Medical Genetics (의학유전학)-
dc.contributor.departmentDept. of Rehabilitation Medicine (재활의학)-
dc.contributor.departmentDept. of Microbiology (미생물학)-
dc.contributor.departmentDept. of Physiology (생리학)-
dc.contributor.departmentDept. of Molecular Medicine (분자의학)-
dc.contributor.departmentInstitute for Medical Science (의과학연구소)-
dc.citation.volume79-
dc.citation.number7-
dc.citation.startpage622-
dc.citation.titleLife Science-
dc.citation.endpage628-
dc.identifier.doi10.1016/j.lfs.2006.02.008-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0024320506001457?via%3Dihub-


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