계명대학교 의학도서관 Repository

Interleukin 4 receptor is associated with an increase in body mass index in Koreans

Metadata Downloads
Affiliated Author(s)
하은영정인성이미영신동훈배재훈
Alternative Author(s)
Ha, Eun YoungChung, In SungLee, Mi YoungShin, Dong HoonBae, Jae Hoon
Journal Title
Life Science
ISSN
0024-3205
Issued Date
2008
Keyword
IL4RObesityPolymorphismBody mass indexKoreans
Abstract
A body of evidence indicates obesity is an inflammatory state with chronic activation of the immune system. The interleukin 4 receptor (IL4R) single nucleotide polymorphism (SNP), rs 180275 (1902A > G) is well recognized for its association with atopy and other inflammatory diseases. We assessed the possible association of rs 180275 and rs 1805010 with obesity in Korean population. Study subject consisting of 876 Koreans were divided into three groups: subjects with 1) BMI < 25, 2) BMI between 25 and 27, and 3) BMI > 27. Analyses of genotype distributions and allele frequencies of study subjects revealed that rs 180275 polymorphism was associated with an increase in BMI in Korean population (P = 0.009 and 0.011, respectively) while no association was found between rs 1805010 and obesity. We observed significantly lower percentage of rs 180275 G allele in subjects with BMI > 27 than in subjects with BMI ≤ 27 (9.9% vs. 16.0%). Logistic regression analysis revealed that the odds ratio (OR) for an increase in BMI associated with the G vs. A allele was 0.57 [95% Confidence interval (CI) = 0.39–0.85, p = 0.002], which strongly implicates the protective role of rs 180275 G allele against an increase in BMI. Haplotype analysis revealed no association was present between rs 180275 and rs 1805010 polymorphisms. The frequency of rs 180275 G allele is significantly lower in subjects with BMI > 27, suggesting the protective role of IL4R rs 180275 G allele against an increase in BMI in Korean population.

Keywords
IL4R;
Obesity;
Polymorphism;
Body mass index;
Koreans
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.