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Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels

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Author(s)
Jae-We ChoWon-Ki BaekSeong-Il SuhSe-Hwan YangJun ChangYoung Chul SungMin-Ho Suh
Publication Year
2001
Keyword
hepatitis C viruscore proteincyclin Ehepatocarcinogenesis
Abstract
Aims/Background: The hepatitis C virus (HCV) core protein is known to play an important role in hepatocarcinogenesis. Recent studies have suggested that the increased proliferation rate of hepatocytes is a major risk factor for the development of hepatocellular carcinoma. In this study, we investigated whether the HCV core protein promotes the cell growth rate through the modulation of cyclin E expression levels. Methods/Results: HCV core stable transfectant Rat-1 cell lines showed a markedly increased proliferation rate compared to mock cells. Cyclin E expression and its associated kinase activities were remarkably increased in HCV core stable transfectants. Cyclin E mRNA levels were also upregulated in these cell lines. Conclusions: Our data suggest that the HCV core protein promotes cell proliferation through upregulation of the cyclin E expression levels, implying this property of HCV core protein plays an important role in hepatocarcinogenesis
Keywords:
hepatitis C virus;
core protein;
cyclin E;
hepatocarcinogenesis
Department
Dept. of Microbiology (미생물학)
Publisher
school of Medicine
Citation
Liver International, Vol.21(2) : 137-142, 2001
Type
Article
ISSN
0106-9543
DOI
10.1034/j.1600-0676.2001.021002137.x
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/36310
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