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난소절제한 흰쥐에서 식이칼슘량이 골밀도에 미치는 영향

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Affiliated Author(s)
이인규
Alternative Author(s)
Lee, In Kyu
Journal Title
한국영양학회지
ISSN
0367-6463
Issued Date
1996
Keyword
dietary calciumbone mineral densitybone mineral contentovariectomized ratdietary clcium
Abstract
This study was done to evaluate the effect of dietary calcium level (a diet which met 100% or twice the calcium level in AIN-76 diet) on preventing bone loss in ovariectomized rats. Forty Sprague-Dawley female rats(body weight 200±5g) were divided into two groups. One group were ovariecotomized (Ovx) while the others received sham operation(Sham). Thereafter, each rat group was further divided into normal calcium diet(0.52%) and high calcium diet(1.04%) subgroups. All rats were fed on experimental diet and deionized water ad libitum for 8 weeks. The total body, spine and femur bone mineral densities and bone mineral contents were measured by Dual Energy X-ray Absorptiometry, Eight weeks following operation, ovariectomized rats fed a high calcium diet had a significantly higher total bone mineral content, total bone calcium content, spine bone mineral density, spine bone mineral content and femur bone mineral content than ovariectomized rats fed control calcium diet. The correlation between dietary calcium intake level and spine bone mineral density were positive, but there was no correlation between dietary calcium intake and femur bone mineral density. The findings from the present study demonstrated that bone loss due to ovarian hormonal deficiency can be partially prevented by a high calcium diet. Futhermore, these findings support the strategy of the use of a high calcium diet in the prevention of estrogen depleted bone loss(postmenopausal osteoporosis).
Alternative Title
The Effect of Dietary Calcium Level on Bone Mineral Density and Bone Mineral Content in Ovariectomized Female
Rats
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
김경희 et al. (1996). 난소절제한 흰쥐에서 식이칼슘량이 골밀도에 미치는 영향. 한국영양학회지, 29(6), 590–596.
Type
Article
ISSN
0367-6463
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36348
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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