Metallo-β-Lactamase-Producing Pseudomonas spp. in Korea: High Prevalence of Isolates with VIM-2 Type and Emergence of Isolates with IMP-1 Type

Abstract

PURPOSE: Two Korean nationwide studies showed that metallo-beta-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. MATERIALS AND METHODS: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. RESULTS: Alleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. CONCLUSION: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.

1) 대상자의 성별에 따른 성생활 특성의 차이는 성태도 (t=2.399, p=0.018), 성행위 (t=3.182, p=0.002)에서 유의한 차이를 나타냈다. 성태도의 경우 자궁절제술을 받은 여성은 3.25(±0.48), 배우자는 3.42(±0.43)으로 나타났으며, 성행위의 경우 자궁절제술을 받은 여성은 3.13(±0.55), 배우자는 3.36(±0.36)으로 나타났다.