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말기신부전 환자에서 투석에 따른 혈관 경직도의 변화

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Affiliated Author(s)
김기식한성욱허승호김윤년김권배강미정한승엽박성배김현철
Alternative Author(s)
Kim, Kee SikHan, Seong WookHur, Seung HoKim, Yoon NyunKim, Kwon BaeHan, Seung YeupPark, Sung BaeKim, Hyun ChulKang, Mi Jung
Journal Title
순환기
ISSN
1225-164X
Issued Date
2004
Keyword
PulseArterialDialysisAtherosclerosisKidney failure
Abstract
In dialysis patients,
the cardiovascular mortality is 10 to 20 times higher than that in the general population. The increased arterial stiffness in patients with end-stage renal disease (ESRD) is an independent predictor of all-cause mortality. The arterial stiffness and atherosclerotic markers were evaluated in patients with ESRD treated with and without hemodialysis (HD) or peritoneal dialysis (PD). Subjects and Methods:14 hemodialysis (mean dialysis duration 19.6 months), 14 peritoneal dialysis (mean dialysis duration 26.1 months) and 14 patients with ESRD prior to initiation of dialysis, and 27 age-sex matched controls were enrolled. The calculated central pulse pressure, plasma homocysteine, serum C-reactive protein, left ventricular mass index and aortic pulse wave velocity (PWV) were measured. Results:Patients with ESRD treated with and without dialysis had greater increases in their arterial stiffness and advanced atherosclerosis compared with the controls. However, there was no difference in the arterial stiffness and atherosclerotic markers before and after the dialysis treatment, or in the dialysis modality (HD, PD) of patients with ESRD. In a multiple regression model, PWV in patients with ESRD was explained by the level of plasma homocysteine (β=0.396;p=0.027). Conclusion:Atherosclerosis and arterial stiffness in patients with ESRD may not be affected by dialysis treatment or modality. In patients with ESRD, the level of plasma homocysteine is independently associated with arterial stiffness. (Korean Circulation J 2004;34(9):865-873) KEY WORDS:Pulse;Arterial;Dialysis;Atherosclerosis;Kidney failure.
Alternative Title
The Change of Arterial Stiffness According to Dialysis in Patients with End-Stage Renal Disease
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
이영수 et al. (2004). 말기신부전 환자에서 투석에 따른 혈관 경직도의 변화. 순환기, 34(9), 865–873.
Type
Article
ISSN
1225-164X
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36764
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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