한국인의 인후두암과 Helicobacter Pylori균의 상관관계에 대한 고찰

Abstract

Background and Objectives：Several studies have implicated Helicobacter pylori as a risk factor in laryngopahryngeal cancer, but other studies disagree. We investigate the possibility that H. pylori as a cause of squamous cell carcinoma of pharynx and larynx in Korean population. Subjects and Methods：A total of 30 patients with laryngopharyngeal cancer and 41 control subjects with benign layngeal disease. Campylobacter-Like Organism (CLO) test and Cresyl-Violet stain was performed on 71 patients to identify H. pylori infection. Tissue samples were collected from tumoral tissue and benign laryngeal diseases and mucosa at posterior arytenoid area adjacent to esophagus. Results：H. pylori was detected in 5 (16.7%) of the 30 patients with laryngopharyngeal cancer, 5 (12.2%) of the 41 patients with benign laryngeal diseases (p=0.733). The correlation between H. pylori infection and laryngopharyngeal cancer was no significant difference [OR=2.73, 95% CI (0.30-24.99)]. Conclusions：Our study shows H. pylori infection of laryngopharyngeal mucosa is not related to the possible etiologic association squamous cell carcinoma of larynx and pharynx in Korean population. (J Clinical Otolaryngol 2014;25:37-43)