Propofol이 신경간세포의 전압의존성 칼륨통로에 미치는 영향

Abstract

Background : Human neural stem cells have at least two types of voltage-dependent potassium channels including inward and outward rectifying potassium channels. Methods : Voltage-dependent potassium currents were measured in cultured human neural stem cells using the whole cell patch-clamp techniquebefore and after application of 0.1 mM propofol. Result : Propofol was found to reversibly block the outward rectifying potassium current (p<0.05), while the anesthetics did not alter the characteristics of inward rectifying potassium current. Conclusion : These results show that propofol may strongly affect the outward potassium channel in human neural stem stells and also suggest a need for investigation into the effect of propofol on the functional regulation of human neural stem cells.