흰쥐에서 체중, 수분섭취량 및 혈액학적 변동에 대한장시간의 Head-down Suspension의 영향

Abstract

Background : This study was aimed to observe the changes in body weight, water intake and hematological data during and after long-term head-down suspension (HDS) in rats. HDS rats induced by tail suspension has evolved as a useful model for the simulation of a microgravity or zero-gravity environment. Methods : Unanesthetized, unrestrained, male Sprague-Dawley rats, weighing 230-370 g, were subjected to either a horizontal position (control horizontal, CH rats) of a 45° head-down suspension (HDS rats) for 4 weeks. We determined the body weight and daily water intake in both CH and HDS rats. Result : In CH rats, body weight was significantly increased (p<0.05) after 4 weeks of experiment, whereas the body weight of HDS rats was only showed a small increased but was significantly decreased (p<0.05) after 4 weeks of HDS compared with that of CH rats. Conclusion : These results represent that the long-terms HDS could attenuate the increase in body weight of young rats and induce the decrease in hematololgical data, especially in the characteristics of red blood cell.