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Head-down Suspension 쥐에서 유도된 시상하부의 Nariuretic Peptide mRNA 발현 변화

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Affiliated Author(s)
배재훈송대규신동훈
Alternative Author(s)
Bae, Jae HoonSong, Dae KyuShin, Dong Hoon
Journal Title
항공우주의학
ISSN
1738-2548
Issued Date
2003
Keyword
Head-down suspensionNatriuretic peptide mRNAAtrial natriuretic peptideC-type natriuretic peptideCNP and ANP mRNAHypothalamus
Abstract
Background: Head-down suspension (HDS) of rats has been used as a model for simulation of a microgravity environment.
Methods : Unanesthetized, unrestrained, male Sprague-Dawley rats were subjected to either a horizontal position (control rats) or a-45° head down tilt using the tail traction technique (HDS rats).
Results: After 4 weeks of HDS, the expression of ANP mRNA expression was significantly (p<0.01) increased in the hypothalamus of HDS rats.
Conclusion : These results represent that the hypothalamic syntheses of natriuretic peptides are differently responded and the role of CNP is augumented to compensate for the decrement of ANP action in the central nervous system following 4 weeks of HDS.
Alternative Title
Changes in Hypothalamic Expressions of Natriuretic Peptide mRNA following Head-down Suspension in Rats
Department
Dept. of Physiology (생리학)
Dept. of Preventive Medicine (예방의학)
Brain Research Institute (뇌연구소)
Publisher
School of Medicine
Citation
배재훈 et al. (2003). Head-down Suspension 쥐에서 유도된 시상하부의 Nariuretic Peptide mRNA 발현 변화. 항공우주의학, 13(1), 7–12.
Type
Article
ISSN
1738-2548
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37200
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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