흰쥐에서 Head-down Suspension으로 유도된 신장의 Natriuretic Peptide 및 수용체 mRNA 발현 변화

Abstract

Background : Head-down suspension (HDS) of rats has been used as a model for the simulation of a microgravity environment. Atrial natriuetic pepdie (ANP), C-type natriuretic peptides (CNP) and their receptors are found in the kidney. Methods : Unanesthetized, unrestrained, male Sprague-Dawley rats were subjected to either a horizontal position (controlrats) of a 45° head-down tilt using the tail-traction technique (HDS rats). Result : After 4 weeks of HDS, the expression of ANP mRNA significantly (p<0.01) decreased, while CNP, showed a slightly decreasing tend in the kidney of rats following HDS. Conclusion : These results suggest that the renal adaptation following 47 weeks of HDS exerts to maintain the blood volume and electrolyte balance through attenuation of systheses in the natriuretic peptide and its binding rece3ptor, expecially in ANP rather than in CNP systems.