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한국인에서 Tigecycline 사용시 부작용 발생 빈도 및 유발 인자에 대한 연구

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Author(s)
소인태이지연현미리김현아류성열
Publication Year
2018
Keyword
Adverse drug reactionMultiple-drug resistanceTigecycline
Abstract
Tigecycline is a broad spectrum antibiotic which has been used
for complicated intra-abdominal infection and complicated skin
and soft tissue infection by multi-drug resistant bacteria.
However recent meta-analysis studies have raised a concern
for adverse events of tigecycline. We analyzed retrospectively
adverse events, associated factors of adverse events in multidrug
resistant bacteria caused infections treated with
tigecycline in Korean patients. One hundred-sixty patients
treated with tigecycline from July 2009 to September 2013
were enrolled in this study. Their clinical and microbiologic data
were reviewed. History of invasive procedure within 7 days and
recent operation within 3 months were associated with adverse
events. The most common adverse events were nausea and
vomiting. Associated factors of nausea were soft tissue injury
and recent operation within 3 months. In this study, nausea was
the most common adverse event in patients who received
tigecycline. Although it is not serious complication, monitoring
of adverse events is required to increase compliance.
Alternative Title
Incidence and Associated Factor of Adverse Events of Tigecycline Therapy in Korean Patients
Department
Dept. of Internal Medicine (내과학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.37(1) : 1-8, 2018
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/37222
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