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Prognostic value of TZAP expression in various cancers: TCGA data analysis

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Author(s)
Won Jin ParkYu Ran HeoJae Ho Lee
Publication Year
2018
Keyword
TCGATelomereTZAPZBTB48
Abstract
The zinc finger protein ZBTB48 is a telomere-associated
factor and renamed it as telomeric zinc finger-associated
protein (TZAP). It binds preferentially to long telomeres
competing with TRF1 and TRF2. However, its expression in
cancers has not been performed. In the present study, we
analyzed the prognosis of TZAP expression in 22 kinds of
cancers by using TCGA data analysis. TZAP expression had a
prognostic value in cervical, colon, and pancreatic cancers.
When sorting the patients differently, it got the significance in
bladder, breast, kidney, brain, and lung cancers. TZAP
expression was associated with better prognosis in bladder,
breast, cervical, lung, and pancreatic cancers. However, it
showed poorer survival results in colon, kidney, and brain
cancers. This result suggested that TZAP expression appears
to be a possible prognosis marker in various cancers.
Department
Dept. of Anatomy (해부학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.37(1) : 17-21, 2018
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/37223
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