Prognostic value of TZAP expression in various cancers: TCGA data analysis
- Won Jin Park; Yu Ran Heo; Jae Ho Lee
- Publication Year
- TCGA; Telomere; TZAP; ZBTB48
- The zinc finger protein ZBTB48 is a telomere-associated
factor and renamed it as telomeric zinc finger-associated
protein (TZAP). It binds preferentially to long telomeres
competing with TRF1 and TRF2. However, its expression in
cancers has not been performed. In the present study, we
analyzed the prognosis of TZAP expression in 22 kinds of
cancers by using TCGA data analysis. TZAP expression had a
prognostic value in cervical, colon, and pancreatic cancers.
When sorting the patients differently, it got the significance in
bladder, breast, kidney, brain, and lung cancers. TZAP
expression was associated with better prognosis in bladder,
breast, cervical, lung, and pancreatic cancers. However, it
showed poorer survival results in colon, kidney, and brain
cancers. This result suggested that TZAP expression appears
to be a possible prognosis marker in various cancers.
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