Prognostic value of TZAP expression in various cancers: TCGA data analysis

Authors
Won Jin ParkYu Ran HeoJae Ho Lee
Department
Dept. of Anatomy (해부학)
Citation
Keimyung Medical Journal, Vol.37(1) : 17-21, 2018
Abstract
The zinc finger protein ZBTB48 is a telomere-associated factor and renamed it as telomeric zinc finger-associated protein (TZAP). It binds preferentially to long telomeres competing with TRF1 and TRF2. However, its expression in cancers has not been performed. In the present study, we analyzed the prognosis of TZAP expression in 22 kinds of cancers by using TCGA data analysis. TZAP expression had a prognostic value in cervical, colon, and pancreatic cancers. When sorting the patients differently, it got the significance in bladder, breast, kidney, brain, and lung cancers. TZAP expression was associated with better prognosis in bladder, breast, cervical, lung, and pancreatic cancers. However, it showed poorer survival results in colon, kidney, and brain cancers. This result suggested that TZAP expression appears to be a possible prognosis marker in various cancers.
Keywords
TCGATelomereTZAPZBTB48
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/37223
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2018
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
Keimyung Author(s)
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