13번 삼염색제를 동반한 급성 미분화성 백혈병 1례

Other Titles
A Case of Acute Undifferentiated Leukemia with Trisomy 13
Authors
김재룡김은진전동석최귀전하정숙권기영
Department
Dept. of Laboratory Medicine (진단검사의학); Dept. of Internal Medicine (내과학)
Citation
대한혈액학회지, Vol.34(1) : 148-152, 1999
ISSN
1125-0546
Abstract
The diagnosis of acute undifferentiated leukemia is made when the leukemic cells cannot be classified using morphologic and cytochemical analyses, and do not express myeloid or lymphoid antigens. Trisomy 13 is a rare primary chromosomal abnormality in acute leukemia and associated with lineage inconsistency and poor prognosis. We report a rare case of acute undifferentiated leuksmia showing negativity in periodic acid-Schiff(PAS) and myeloperoxidase(MPO) without any lineage-specific cell suface marker expression and having trisomy 13. The patient was a 72-ysar-old male who visited our hospital becauss of anemia and general weakness. On examination, leukocytosis with proliferated blasts(76%) in peripheral blood was noted. Bone marrow aspirate showed blast proliferation(74%) tilth morphologically hand-mirror type. The blast expressed CD34(96%) and HLA-DR(76%) in immunophenotyping. Cytogsnetic study of bone marrow cells showed 46,XY,+13,-21[15]/46,XY[5]. Induction chemotherapy was failed and differentiation to monocytic series was noted.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/37230
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
전동석; 김재룡; 하정숙; 권기영
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