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만성 폐쇄성 폐질환(COPD) 환자에서 운동 시 발생하는 산소 불포화 반응과 관련된 인자

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Affiliated Author(s)
이미영노병학최원일
Alternative Author(s)
Lee, Mi YoungRho, Byung HakChoi, Won Il
Journal Title
결핵 및 호흡기 질환
ISSN
1738-3536
Issued Date
2011
Abstract
Background: The causes of exertional desaturation in patients with COPD can be multifactorial. We aimed to
investigate factors predict exertional desaturation in patients with moderate to severe COPD.
Methods: We tested 51 consecutive patients with stable COPD (FEV1/FVC, 40±13% predicted). Patients performed
a six minute walk test (6MWT). Pulse oxymetric saturation (SpO2) and pulse rate were recorded.
Results: Oxygen desaturation was found in 15 subjects after 6MWT, while 36 subjects were not desaturated. Lung
diffusing capacity was significantly lower in desaturation (DS) group (62±18% predicted) compared with not
desaturated (ND) group (84±20, p<0.01). However there was no statistical difference of FEV1/FVC ratio or residual
volume between two groups. The pulse rate change was significantly higher in the desaturated compared with
the not desaturated group. Six minute walking distance, subjective dyspnea scale, airflow obstruction, and residual
volume did not predict exertional oxygen desaturation. Independent factors assessed by multiple logistic regression
revealed that a pulse rate increment (odd ratio [OR], 1.19; 95% confidence interval [CI], 1.01∼1.40; p=0.02), a
decrease in baseline PaO2 (OR, 1.105; 95% CI, 1.003∼1.218; p=0.04) and a decrease in lung diffusing capacity
(OR, 1.10; 95% CI, 1.01∼1.19; p=0.01) were significantly associated with oxygen desaturation. Receiver operator
characteristic (ROC) analysis showed that an absolute increment in pulse rate of 16/min gave optimal discrimination
between desaturated and not desaturated patients after 6MWT.
Conclusion: Pulse rate increment and diffusion capacity can predict exertional oxygen desaturation in stable COPD
patients with moderate to severe airflow obstruction.
Key Words: Pulmonary Disease, Chronic Obstructive; Heart Rate; Anoxia
Alternative Title
Factors Related to Exertional Oxygen Desaturation in Patients with COPD
Department
Dept. of Preventive Medicine (예방의학)
Dept. of Radiology (영상의학)
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
심상우 et al. (2011). 만성 폐쇄성 폐질환(COPD) 환자에서 운동 시 발생하는 산소 불포화 반응과
관련된 인자. 결핵 및 호흡기 질환, 70(6), 498–503. doi: 10.4046/trd.2011.70.6.498
Type
Article
ISSN
1738-3536
DOI
10.4046/trd.2011.70.6.498
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37343
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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