상피성 난소암에서 p53 유전자의 발현

Abstract

It has been recognized that abnormalities of tumor suppressor gene play a significant role in the development of some human tumors. One of the most common genetic alterations seen in human tumors is the mutational inactivation of the tumor suppressor gene p53. Intranuclear p53 accumulation is a common finding in many different human tumors and is associated with a worse prognosis. We examined samples of common epithelial ovarian cancersto assess the prevalence of p53 accumulation and its clinicopathologic correlations, and its prognostic implication, using anti-p53 antibodies and peroxidase immunohistochemistry. Of 40 cases with ovarian cancers(22 cases of serous type, 10 cases of mucinous types, 4 cases of endometrioid type, 3 cases of undifferentiated type, and 1 case of malignant mixed epithelial tumor), a varible degree of p53 immunoreactivity was seen in 27 cases(67.5%). No relationship was seen among p53 overexpression, age, histologic type, stage and mean survival. Strong expression of p53, however, was correlated with cell differentiation and tumor size(p0.02, respectively). These results have implications suggesting hat abnormal expression of p53 occurs frequently in ovarian cancers and p53 is overexpressed more frequently in tumors with poor cell differentiatin & big size.