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Two Cases of Hypophosphatemic Osteomalacia After Long-term Low Dose Adefovir Therapy in Chronic Hepatitis B and Literature Review

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Affiliated Author(s)
김지민김상현권건영
Alternative Author(s)
Kim, Ji MinKim, Sang HyonKwon, Kun Young
Journal Title
대한골대사학회지
ISSN
2287-6375
Issued Date
2014
Abstract
Adefovir dipivoxil (ADV) is a nucleotide used as long-term therapy of chronic hepatitis B. Many published reports have shown that long-term high-dose therapy with adefovir can be associated with proximal renal tubular dysfunction resulting in significant hypophosphatemia, renal insufficiency and osteomalacia. We have encountered two patients who developed evidence of hypophosphatemic osteomalacia while on long-term low-dose adefovir therapy for chronic hepatitis B. We report on its clinical features and its potential resolution with cessation of the drug and supplementation with phosphate. We also reviewed the other published cases associated with hypophosphatemic osteomalacia after low-dose adefovir therapy. The symptoms and the hypophosphatemia improved after cessation of the drug and supplementation with phosphate in most cases. Patients taking adefovir long-term should receive regular investigation of the phosphate level and renal function.
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
Hye Jin Jeong et al. (2014). Two Cases of Hypophosphatemic Osteomalacia After Long-term Low Dose Adefovir Therapy in Chronic Hepatitis B and Literature Review. 대한골대사학회지, 21(1), 76–83. doi: 10.11005/jbm.2014.21.1.76
Type
Article
ISSN
2287-6375
DOI
10.11005/jbm.2014.21.1.76
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37610
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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