변비 약물 치료의 지침 – 어떤 약제를, 언제 사용해야 하는가?
- Affiliated Author(s)
- 박경식
- Alternative Author(s)
- Park, Kyung Sik
- Journal Title
- 대한내과학회지
- ISSN
- 1738-9364
- Issued Date
- 2015
- Abstract
- To manage chronic constipation, dietary and lifestyle modifications should be tried before pharmacological intervention.
Although there is no standardized treatment guideline for medical practice, the key considerations in the choice of laxative include
the treatment duration, dosing schedule, type of agent, effects and side effects of the agent, and cost. The first-line treatment is a
bulking or osmotic laxative. If the patient is still symptomatic, the physician can add or switch to other laxatives. Next, prucalopride,
a highly selective 5-hydroxytryptamine 4 (5-HT4) receptor agonist, could be considered. If the constipation is refractory to
combination therapy with conventional laxatives and prucalopride, patients should be referred for further evaluation, including
physiological testing. (Korean J Med 2015;88:22-26)
Keywords: Constipation; Laxatives
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