차세대 완하제

Other Titles
New Generation Laxatives
Authors
홍성노신정은홍경섭정기욱이태희이봉은박선영김성은박경식최석채대한소화기기능성질환ㆍ운동학회 변비 및 항문직장기능 연구회
Department
Dept. of Internal Medicine (내과학)
Issue Date
2015
Citation
대한내과학회지, Vol.88(1) : 9-14, 2015
ISSN
1738-9364
Abstract
A significant proportion of chronic constipation patients are dissatisfied with their treatment. Recently, a number of new medications have been introduced for patients refractory to conventional laxatives, such as prucalopride, lubiprostone, linaclotide, and elobixibat. Prucalopride is a novel gastrointestinal prokinetic agent that acts as a 5-hydroxytryptamine type 4 (5-HT4) agonist. Compared with older nonselective 5-HT4 agonists, the higher selectivity of prucalopride for 5-HT4 receptors can reduce the risk of significant adverse cardiovascular events. Prucalopride improves stool frequency and consistency, and reduces the need for rescue medications. Lubiprostone, a chloride channel activator, increases the secretion of intestinal fluid, improves the stool frequency and consistency, and reduces straining. Linaclotide, a guanylate cyclase-C agonist, is effective in treating patients with chronic constipation and its effect on visceral sensitivity, as shown mainly in animal studies, provides an attractive pharmaceutical option for patients with irritable bowel syndrome with constipation. Elobixibat is an ileal sodium-dependent bile acid transporter inhibitor that blocks the enterohepatic circulation of bile acids, increasing the bile acid concentration in the intestine, which accelerates colonic transit and softens the stool. A phase III trial of the treatment of chronic constipation and irritable bowel syndrome with constipation is underway. The clinical application of new-generation laxatives will contribute to the management of chronic constipation refractory to conventional laxatives. (Korean J Med 2015;88:9-14) Keywords: Constipation; Laxatives; Prucalopride; Lubiprostone; Linaclotide
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/37710
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
박경식
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