특발성 IgM 단일클론성 감마글로불린병증 1 예

Abstract

A 66-year-old fanner was admitted with dizziness and dyspnea on exertion. The peripheral blood showed hematocrit of 8.4gm/dl with microcytic hypochromic anemia, serum iron of 26 /zg/dl, total iron binding capacity of 316 /ig/'dl, and ferritin of 1.64 ng/ml. The bone marrow smear revealed normal cellularity with 4:1 of myeloid/erythroid ratio, 2.9% of plasmacytosis with normal morphology, and no stainable iron. Protein electrophoresis revealed prominent monoclonal gammopathy in gamma-fraction and arc of IgM-kappa type in both serum and 'irine. After observation of 1 year with iron supplementation, M-component of serum and urine is increased 33% and 71% from initial value. This case is 1st case of idiopathic IgM monoclonal gammopathy in korea which associated with iron deficiency anemia, and regular examination is needed whether the disorder is progression to the lympho-proliferative malignancy.