Primary Gastrointestinal Lymphoma:A Comparison of Survival Rates between Gastric and Intestinal Non-Hodgkin's Lymphoma

Abstract

Purpose : The purpose of this study was to evaluate the differences in survival rates between primary gastric and intestinal gastro intestinal non-Hodgkin's lymphoma (NHL) and to investigate risk factors for survival. Materials and Methods :We reviewed survival rates and risk factors in 60 cases with stage I and II primary g astro intestinal lymphomas treated at Keimyung University Hospita l be tween January 1972 and Aug ust 1999. Results : No differences in sex , age , histology, stage , or percentage of curative resection were observed between primary gastric and intestinal lymphoma. The overall 10-year survival rates of gastric and intestinal NHL were 68.1% and 39.6%, respectively (p＜ 0.05). The overall 10-year survival rates in stage I gastric and intestinal NHL were 66.7% and 70.0%, respectively, while those in stage II were 65.1% and 23.7%, respectively (p＜ 0.00 1). A multivariate analysis of risk factors for survival revealed that the site of origin (5.68, CI=1.8 17.5) and stage (4.22, CI=1.19 14.85) were significantly correlated with prognosis(p＜ 0.05). There was no significant difference in the expression of bcl-2 and p53 between gastric and intestinal NHL. Furthe rmorebcl-2 and p53 expressions were not correlated with the prognosis . Conclusion: This study indicates that stage II primary intestinallymphoma has lower survival rate than gastriclymphoma.