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Effect of Acute Ethanol Intoxication on Hepatic Rhodanese Activity in Rats with Extrahepatic Cholestasis

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Affiliated Author(s)
문교철김여희곽춘식
Alternative Author(s)
Mun, Kyo CheolKim, You HeeKwak, Chun Sik
Journal Title
대한의생명과학회지
ISSN
1738-3226
Issued Date
2004
Abstract
Liver and serum rhodanese activities were determined in acute ethanol intoxicated rats with extrahepatic cholestasis induced by common bile duct ligation (CBD) to manifest the biochemical background of alcohol drinking hazard under the hepatobiliary disease. Liver cytosolic and microsomal rhodanese activities and these Vmax values in CBD ligated rats with acute ethanol intoxication were found to be decreased much more than that in CBD ligation alone. However, the difference of Km value on above hepatic enzyme was not found between the experimental groups. On the other hand, serum rhodanese activity in CBD ligated rats with acute ethanol intoxication was greater increased more than that in CBD ligation alone. These results indicate that the biosynthesis of the hepatic rhodanese decreases and the serum rhodanese activity increases in cholestasis combined with acute ethanol intoxication, reflecting damage of aggravated hapatocytic membrane. Accordingly, the resulting data supported the fact that alcoholic drinks were enzymologically harmful to the hepatobiliary disease.
Department
Dept. of Biochemistry (생화학)
Publisher
School of Medicine
Citation
Ki-Suk Choi et al. (2004). Effect of Acute Ethanol Intoxication on Hepatic Rhodanese Activity in Rats with Extrahepatic Cholestasis. 대한의생명과학회지, 10(2), 99–105.
Type
Article
ISSN
1738-3226
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38308
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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