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Effects of Extrahepatic Cholestasis on Liver and Serum β-D-Mannosidase Activities in Ethanol Intoxicated Rats

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Affiliated Author(s)
곽춘식
Alternative Author(s)
Kwak, Chun Sik
Journal Title
대한의생명과학회지
ISSN
1738-3226
Issued Date
2004
Abstract
Liver and serum β-D-mannosidase activities were determined in ethanol intoxicated rats with extrahepatic cholestasis induced by common bile duct ligation (CBD) to manifest the biochemical background of alcohol drinking hazard under the hepatobiliary disease. Liver β-D-mannosidase activity and its Vmax value in CBD ligated rats with chronic ethanol intoxication were found to be significantly decreased than that in CBD ligation alone. However, the difference of Km value on above hepatic enzyme was not found between the experimental groups. On the other hand, serum β-D -mannosidase activity in CBD ligated rats with chronic ethanol intoxication was increased more than that in CBD ligation alone. These results indicate that the biosynthesis of the hepatic β-D-mannosidase decreases and the serum β-D-mannosidase activity increases in cholestasis combined with chronic ehtanol intoxication, reflecting damage of aggravated hapatocytic membrane. Accordingly, the resulting data supported the fact that alcoholic drinks were enzymologically harmful to the hepatobiliary disease.
Department
Dept. of Biochemistry (생화학)
Publisher
School of Medicine
Citation
Si-Woo Bae et al. (2004). Effects of Extrahepatic Cholestasis on Liver and Serum β-D-Mannosidase Activities in Ethanol Intoxicated Rats. 대한의생명과학회지, 10(1), 35–42.
Type
Article
ISSN
1738-3226
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38310
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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