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Effects of High Taurocholic Acid Load on Liver Lysosomal Cathepsin B and D, and Acid Phosphatase Activities in Rats with Choledocho-Caval Shunt

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Affiliated Author(s)
김여희곽춘식
Alternative Author(s)
Kim, You HeeKwak, Chun Sik
Journal Title
대한의생명과학회지
ISSN
1738-3226
Issued Date
2004
Abstract
The effects of intravenous administration of high concentration of taurocholic acid (TCA) on cathepsin B and D, and acid phosphatase activities in rat liver lysosome were studied. These liver lysosomal enzymes were determined from the experimental rats with choledocho-caval shunt (CCS). The activities of liver lysosomal cathepsin B and D, and acid phosphatase were found to be significantly increased in the CCS plus TCA injection group than in control group, such as group of CCS alone group. However, these hepatic enzyme activities did not change in the CCS plus tauroursodeoxycholic acid injection group. The above results suggest that TCA stimulates the biosynthesis of the lysosomal cathepsin B and D, and acid phosphatase in the liver.
Department
Dept. of Biochemistry (생화학)
Publisher
School of Medicine
Citation
Hye-Jung Choi et al. (2004). Effects of High Taurocholic Acid Load on Liver Lysosomal Cathepsin B and D, and Acid Phosphatase Activities in Rats with Choledocho-Caval Shunt. 대한의생명과학회지, 10(4), 429–434.
Type
Article
ISSN
1738-3226
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38311
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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