기니픽에서 Povidone-Iodine에 의한 이독성의 형태학적 연구

Other Titles
Morphologic Study of the Ototoxicity of Povidone-Iodine Preparation to the Guinea Pig Middle Ear
Authors
김중강김종훈안병훈박관규
Department
Dept. of Otorhinolaryngology (이비인후과학); Dept. of Pathology (병리학)
Issue Date
1993
Citation
대한이비인후과학회지, Vol.36(4) : 624-632, 1993
ISSN
1225-035X
Abstract
It is important to be aware of the potential ototoxicity of any drug, vehicle, or antibiotic that is used in the middle ear. It has been suggested that antiseptic which could trickle into the middle ear through a perforated tympanic membrane during the skin sterilization preceding otosurgery might cause inner ear damage, resulting in deafness. Povidone-iodine solution and povidone-iodine scrub, in combination or separately, are commonly used preoperative antiseptics in the middle ear surgery. The ototoxicity of topically applied povidone-iodine preparation in chinchilla was verified electrophysiologically by Morizono et al (1982), but they did not perform histologic verification of the functional findings because animals were followed only to 24 hours after antiseptic application. In the present study, the ototoxicity of povidone-iodine solution and scrub, when topically applied to the middle ear of the guinea pig. was studied by means of light microscopy. There are total loss of the outer hair cells and vacuolation of the stria vascularis in the basal and second turns of the organ of Corti, but partial loss of the supporting cells in the second turn of the organ of Corti. Conclusively, the ototoxicity of povidone-iodine preparation is verified histologically.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/38342
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Keimyung Author(s)
김중강; 안병훈; 김종훈; 박관규
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