계명대학교 의학도서관 Repository

신 이식 후 당대사에 미치는 Tacrolimus의 영향

Metadata Downloads
Author(s)
한승엽박성배김현철
Alternative Author(s)
Han, Seung YeupPark, Sung BaeKim, Hyun Chul
Issued Date
2003
Abstract
Purpose: Posttrarisplant diabetes mellitus (PTDM) is one of the feared complications of the immunosuppressive agents following renal transplantation. Despite advances of immunosuppressive therapy, including the introduction of the steroid-sparing calcineurin inhibitors, cyclospoiine and tacrolimus, the incidence rate remains greater than 10~30%. Methods: This prospective study investigated the infiuence of tacrolimus on glucose metabolism before and after transplantation for twenty patients without known glucose metabolism abnormalities. Results: The overall incidence of PTDM was 30% and was developed within 3 months after renal transplantation in majority of cases. During tacrolimus administration, fasting blood glucose increased from a median of 87.0 mg/L to 103.5 mg/dL (P<0.05), and Insulin sensitivity decreased in 15 of 20 patients, from a median of 1.6 mg/dL/min to 1.2 mg/dL/min (P<0.05). Insulin secretion decreased from 1918.3μU X min/mL to 1018.2μU X min/mL (P<0.05), whereas insulin resistance did not change. Conclusion: These results indicate that diminished insulin secretion response to a glucose load rather than insulin resistance was proved as the main pathogenesis of PTDM in renal transplant recipients treated with tacrotimus. Higher tacrolimus trough level, older age, and higher weight were more frequently seen in the PTDM group than normal group, although the difference Med to reach statistical significance. Further prospective studies with a greater number of patients are needed to define the risk factor for PTDM.
Alternative Title
Influence of Tacrolimus on Glucose Metabolism before and after Renal Transplantation
Department
Dept. of Internal Medicine (내과학)
Kidney Institute (신장연구소)
Publisher
School of Medicine
Citation
대한이식학회지, Vol.17(1) : 51-55, 2003
Type
Article
ISSN
1598-1711
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/38415
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
Authorize & License
  • AuthorizeOpen
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.