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뉴우모시스티스 카리니 폐렴에서 폐포 대식세포와 뉴우모시스티스 카리니의 상호 반응에 관련된 Surfactant-D 단백질 및 TNF- α의 발현

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Affiliated Author(s)
권건영박관규장은숙박창권전영준
Alternative Author(s)
Kwon, Kun YoungPark, Kwan KyuChang, Eun SookPark, Chang KwonJeon, Young June
Journal Title
대한병리학회지
ISSN
0379-1149
Issued Date
1999
Abstract
Alveolar macrophages participate in the host defense against P. carinii, but the mechanisms in degradation and clearance of the organism from lung has not been well established. We observed the transmission and scanning electron microscopic features and evaluated the expression of TNF-alpha and Surfactant-D in the interaction of P. carinii with alveolar macrophages. Expression of TNF-alpha and Surfactant-D in the experimentally induced P. carinii pneumonia in rat was examined by immunohistochemistry and immunoelectron microscopy. Electron microscopically, the alveolar macrophages phagocytized trophozoites and cysts of P. carinii micro-organisms. Immunohistochemically TNF-alpha was strongly expressed in the cytoplasms of alveolar macrophages. Postembedding immunogold labeling for Surfactant-D protein was expressed on the pellicles of trophozoites and cysts, P. carinii micro-organisms in the cytoplasms of macrophages, free floating surfactant materials and multilamellar bodies of type II epithelial cells. We conclude that alveolar macrophages interacted with P. carinii micro-organisms respond with increased expression of TNF-alpha. TNF-alpha may bind to P. carinii and exert a direct toxic effect upon the micro-organisms. Surfactant-D protein may augment binding of P. carinii to the alveolar macrophages and enhance the clearance of the micro-organisms.
Key Words: Pneumocystis carinii; Alveolar macrophages; TNF-alpha; Surfactant-D; Immunogold labeling
Alternative Title
Expression of Surfactant-D Protein and TNF-α in the Interaction of Pneumocystis Carinii and Alveolar Macrophages in Pneumocystis Carinii Pneumonia.
Department
Dept. of Pathology (병리학)
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
권건영 et al. (1999). 뉴우모시스티스 카리니 폐렴에서 폐포 대식세포와 뉴우모시스티스 카리니의 상호 반응에 관련된 Surfactant-D 단백질 및 TNF- α의 발현. 대한병리학회지, 33(9), 684–694.
Type
Article
ISSN
0379-1149
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/38611
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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